[It's sure a 180 alright. But her question just makes him sneer, his tone sour.]

I'm not amused. Hardly at all, are you kidding me? I've been blacking out for god knows how long and it seems every bloody time I wake up, there's a new dead body. My damn brain is going haywire, there's a murderer just lazily murdering like no one's business, I keep losing memories like my skull's a sieve...

[whatchu talkin' bout, willis]

So yes, something is probably "wrong with me"! Wow, excellent guess there, Sherlock!